Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a potential antiparasitic drug target | Homo sapiens |
drug development | the enzyme is a potential antiparasitic drug target | Leishmania donovani |
drug development | the enzyme is a potential antiparasitic drug target | Plasmodium falciparum |
drug development | the enzyme is a potential antiparasitic drug target | Leishmania major |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate | - |
Homo sapiens | |
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate | - |
Leishmania donovani | |
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate | - |
Leishmania major | |
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate | - |
Plasmodium falciparum | |
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Homo sapiens | |
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Leishmania donovani | |
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Leishmania major | |
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Plasmodium falciparum | |
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Homo sapiens | |
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Leishmania donovani | |
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Leishmania major | |
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Plasmodium falciparum | |
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine | - |
Homo sapiens | |
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine | - |
Leishmania donovani | |
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine | - |
Leishmania major | |
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine | - |
Plasmodium falciparum | |
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine | - |
Homo sapiens | |
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine | - |
Leishmania donovani | |
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine | - |
Leishmania major | |
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine | - |
Plasmodium falciparum | |
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Homo sapiens | |
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Leishmania donovani | |
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Leishmania major | |
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Plasmodium falciparum | |
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Homo sapiens | |
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Leishmania donovani | |
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Leishmania major | |
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Plasmodium falciparum | |
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine | - |
Homo sapiens | |
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine | - |
Leishmania donovani | |
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine | - |
Leishmania major | |
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine | - |
Plasmodium falciparum | |
5'-O-triphenylsilyl-2'-deoxyuridine | - |
Homo sapiens | |
5'-O-triphenylsilyl-2'-deoxyuridine | - |
Leishmania donovani | |
5'-O-triphenylsilyl-2'-deoxyuridine | - |
Leishmania major | |
5'-O-triphenylsilyl-2'-deoxyuridine | - |
Plasmodium falciparum | |
5'-pentanoylamino-2',5'-dideoxyuridine | - |
Homo sapiens | |
5'-pentanoylamino-2',5'-dideoxyuridine | - |
Leishmania donovani | |
5'-pentanoylamino-2',5'-dideoxyuridine | - |
Leishmania major | |
5'-pentanoylamino-2',5'-dideoxyuridine | - |
Plasmodium falciparum | |
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine | - |
Homo sapiens | |
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine | - |
Leishmania donovani | |
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine | - |
Leishmania major | |
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine | - |
Plasmodium falciparum | |
5'-tritylamino-2',5'-dideoxyuridine | - |
Homo sapiens | |
5'-tritylamino-2',5'-dideoxyuridine | - |
Leishmania donovani | |
5'-tritylamino-2',5'-dideoxyuridine | - |
Leishmania major | |
5'-tritylamino-2',5'-dideoxyuridine | - |
Plasmodium falciparum | |
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine | - |
Homo sapiens | |
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine | - |
Leishmania donovani | |
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine | - |
Leishmania major | |
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine | - |
Plasmodium falciparum | |
additional information | inhibitor in vivo activity against the parasite, overview | Homo sapiens | |
additional information | inhibitor in vivo activity against the parasite, overview | Leishmania donovani | |
additional information | inhibitor in vivo activity against the parasite, overview | Leishmania major | |
additional information | inhibitor in vivo activity against the parasite, overview | Plasmodium falciparum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Leishmania donovani | |
Mg2+ | - |
Plasmodium falciparum | |
Mg2+ | - |
Leishmania major |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dUTP + H2O | Homo sapiens | - |
dUMP + diphosphate | - |
? | |
dUTP + H2O | Leishmania donovani | - |
dUMP + diphosphate | - |
? | |
dUTP + H2O | Plasmodium falciparum | - |
dUMP + diphosphate | - |
? | |
dUTP + H2O | Leishmania major | - |
dUMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Leishmania donovani | - |
- |
- |
Leishmania major | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dUTP + H2O | - |
Homo sapiens | dUMP + diphosphate | - |
? | |
dUTP + H2O | - |
Leishmania donovani | dUMP + diphosphate | - |
? | |
dUTP + H2O | - |
Plasmodium falciparum | dUMP + diphosphate | - |
? | |
dUTP + H2O | - |
Leishmania major | dUMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
deoxyuridine triphosphate nucleotidohydrolase | - |
Homo sapiens |
deoxyuridine triphosphate nucleotidohydrolase | - |
Leishmania donovani |
deoxyuridine triphosphate nucleotidohydrolase | - |
Plasmodium falciparum |
deoxyuridine triphosphate nucleotidohydrolase | - |
Leishmania major |
dUTPase | - |
Homo sapiens |
dUTPase | - |
Leishmania donovani |
dUTPase | - |
Plasmodium falciparum |
dUTPase | - |
Leishmania major |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
5'-tritylamino-2',5'-dideoxyuridine | - |
Plasmodium falciparum | |
0.0013 | - |
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Plasmodium falciparum | |
0.0028 | - |
5'-O-triphenylsilyl-2'-deoxyuridine | - |
Plasmodium falciparum | |
0.012 | - |
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine | - |
Plasmodium falciparum | |
0.026 | - |
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Plasmodium falciparum | |
0.046 | - |
5'-tritylamino-2',5'-dideoxyuridine | - |
Homo sapiens | |
0.058 | - |
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine | - |
Plasmodium falciparum | |
0.067 | - |
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Plasmodium falciparum | |
0.082 | - |
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Plasmodium falciparum | |
0.088 | - |
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine | - |
Plasmodium falciparum | |
0.089 | - |
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine | - |
Plasmodium falciparum | |
0.099 | - |
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate | - |
Plasmodium falciparum | |
0.189 | - |
5'-pentanoylamino-2',5'-dideoxyuridine | - |
Plasmodium falciparum | |
0.232 | - |
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | - |
Homo sapiens | |
0.298 | - |
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine | - |
Homo sapiens | |
0.304 | - |
5'-tritylamino-2',5'-dideoxyuridine | - |
Leishmania major | |
0.324 | - |
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine | - |
Homo sapiens | |
0.35 | - |
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Leishmania major | |
0.433 | - |
5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine | - |
Leishmania major | |
0.799 | - |
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine | - |
Homo sapiens | |
0.808 | - |
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine | - |
Homo sapiens | |
0.909 | - |
5'-O-triphenylsilyl-2'-deoxyuridine | - |
Homo sapiens | |
0.975 | - |
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine | - |
Plasmodium falciparum | |
1 | - |
5'-O-triphenylsilyl-2'-deoxyuridine | above | Leishmania major | |
1 | - |
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | above | Homo sapiens | |
1 | - |
2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | above | Leishmania major | |
1 | - |
5'-pentanoylamino-2',5'-dideoxyuridine | above | Homo sapiens | |
1 | - |
5'-pentanoylamino-2',5'-dideoxyuridine | above | Leishmania major | |
1 | - |
3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine | above | Leishmania major | |
1 | - |
3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate | above | Leishmania major | |
1 | - |
5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine | above | Leishmania major | |
1 | - |
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine | above | Homo sapiens | |
1 | - |
5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine | above | Leishmania major | |
1 | - |
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine | above | Homo sapiens | |
1 | - |
5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine | above | Leishmania major | |
1 | - |
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate | above | Homo sapiens | |
1 | - |
2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate | above | Leishmania major | |
1 | - |
5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine | above | Leishmania major | |
1 | - |
5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine | above | Homo sapiens |